Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)

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Code	CSB-AP003491HO
Size	US$2391Purchase it in Cusabio online store(only available for customers from the US)
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Target Data

Product Details

Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/μg as determined by LAL method.
Activity	Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0 μg/ml, corresponding to a specific activity of >333 IU/mg in the presence of 50 pg/ml rHuIL-1α.
Target Names	IL1RN
Uniprot No.	O18999
Research Area	Immunology
Alternative Names	IL1RN; IL1RAInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor
Species	Equus caballus (Horse)
Source	E.coli
Expression Region	26-177aa
Complete Sequence	HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ
Mol. Weight	17.4 kDa
Protein Length	Full Length of Mature Protein
Tag Info	Tag-Free
Form	Lyophilized powder
Buffer	Lyophilized from a0.2 µm filteredPBS, pH 7.4
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA	Please contact us to get it.

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Target Data

Function	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Gene References into Functions	This is the first study in an equine model to establish a dosing/redosing protocol, as well as examine the Nab response to capsid and supports further clinical investigation to determine the clinical efficacy of scAAVIL-1ra to treat osteoarthritis. PMID: 25902762 Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy. PMID: 19157767
Subcellular Location	Secreted
Protein Families	IL-1 family
Database Links	KEGG: ecb:100034236 STRING: 9796.ENSECAP00000004056 UniGene: Eca.13123

品牌介绍

武汉华美生物工程有限公司成立于2007年12月，注册资金为5000万元，是一家集科研、生产、销售为一体的国家高新技术企业，以食品安全检测产品生产、诊断试剂原料供应、科研试剂生产、生物技术服务为核心，主要为国内外知名的医药研发公司、诊断试剂生产厂家、政府监管检测机构、高等院校、企业及科研院所等提供相关产品及定制化的技术服务。公司拥有6个研发平台，分别为食品安全检测产品开发平台、高通量基因克隆平台、蛋白质组学的生物标记物高通量筛选平台、生物标记物的免疫性检测方法快速建立平台、四大表达系统的重组蛋白表达平台和科研及诊断用单多抗制备平台。以技术为核心、视质量为生命、奉用户为上帝，竭诚为您提供性价比较高的检测产品及无微不至的售后服务。业务范围主营基因、重组蛋白、抗体、ELISA试剂盒、食品安全检测试剂盒及诊断试剂原料产品。

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